Genome wide association study of 40 clinical measurements in eight dog breeds.
Momozawa Y, Merveille AC, Battaille G, Wiberg M, Koch J, Willesen JL, et al.; Sci Rep 10:6520, 2020
DOI:
10.1038/s41598-020-63457-y
日本語解説:
理研プレスリリース
Genetic characterization of pancreatic cancer patients and prediction of carrier status of germline pathogenic variants in cancer-predisposing genes.
Mizukami K, Iwasaki Y, Kawakami E, Hirata M, Kamatani Y, Matsuda K, et al.; EBioMedicine 60:103033, 2020
DOI:
10.1016/j.ebiom.2020.103033
日本語解説:
理研プレスリリース
Prevalence and Spectrum of Pathogenic Germline Variants in Japanese Patients With Early-Onset Colorectal, Breast, and Prostate Cancer.
Liu X, Takata S, Ashikawa K, Aoi T, Kosugi S, Terao C, et al.; JCO Precision Oncology no. 4:183-191, 2020
DOI:
10.1200/PO.19.00224
日本語解説:
理研プレスリリース
Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease.
Koyama S, Ito K, Terao C, Akiyama M, Horikoshi M, Momozawa Y, et al.; Nat Genet 52:1169-1177, 2020
DOI:
10.1038/s41588-020-0705-3
日本語解説:
理研プレスリリース
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.
Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, et al.; Nat Genet 52:669-679, 2020
DOI:
10.1038/s41588-020-0640-3
日本語解説:
理研プレスリリース
Chromosomal alterations among age-related haematopoietic clones in Japan.
Terao C, Suzuki A, Momozawa Y, Akiyama M, Ishigaki K, Yamamoto K, et al.; Nature 584:130-135, 2020
DOI:
10.1038/s41586-020-2426-2
日本語解説:
理研プレスリリース
GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits.
Matoba N, Akiyama M, Ishigaki K, Kanai M, Takahashi A, Momozawa Y, et al.; Nat Hum Behav 4:308-316, 2020
DOI:
10.1038/s41562-019-0805-1
日本語解説:
理研プレスリリース
Endogenization and excision of human herpesvirus 6 in human genomes.
Liu X, Kosugi S, Koide R, Kawamura Y, Ito J, Miura H, et al.; PLoS Genet 16:e1008915, 2020
DOI:
10.1371/journal.pgen.1008915
日本語解説:
理研プレスリリース
Update on next generation sequencing of pharmacokinetics-related genes: Development of the PKseq panel, a platform for amplicon sequencing of drug-metabolizing enzyme and drug transporter genes.
Fukunaga K, Momozawa Y, Mushiroda T; Drug Metab Pharmacokinet 37:100370, 2020
DOI:
10.1016/j.dmpk.2020.11.005
Genetic and phenotypic landscape of the mitochondrial genome in the Japanese population.
Yamamoto K, Sakaue S, Matsuda K, Murakami Y, Kamatani Y, Ozono K, et al.; Commun Biol 3:104, 2020
DOI:
10.1038/s42003-020-0812-9
日本語解説:
AMEDプレスリリース
Substantially Increased Plasma Coproporphyrin-I Concentrations Associated With OATP1B1*15 Allele in Japanese General Population.
Suzuki Y, Sasamoto Y, Koyama T, Yoshijima C, Nakatochi M, Kubo M, et al.; Clin Transl Sci, 2020
DOI:
10.1111/cts.12889
Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women.
Wong JYY, Zhang H, Hsiung CA, Shiraishi K, Yu K, Matsuo K, et al.; Genomics 112:1223-1232, 2020
DOI:
10.1016/j.ygeno.2019.07.008
Polygenic risk scores in schizophrenia with clinically significant copy number variants.
Taniguchi S, Ninomiya K, Kushima I, Saito T, Shimasaki A, Sakusabe T, et al.; Psychiatry Clin Neurosci 74:35-39, 2020
DOI:
10.1111/pcn.12926
Study profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study.
Takeuchi K, Naito M, Kawai S, Tsukamoto M, Kadomatsu Y, Kubo Y, et al.; J Epidemiol, 2020
DOI:
10.2188/jea.JE20200147
A genome-wide association study on fish consumption in a Japanese population-the Japan Multi-Institutional Collaborative Cohort study.
Suzuki T, Nakamura Y, Matsuo K, Oze I, Doi Y, Narita A, et al.; Eur J Clin Nutr, 2020
DOI:
10.1038/s41430-020-00702-7
A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern.
Suzuki H, Nakamura Y, Matsuo K, Imaeda N, Goto C, Narita A, et al.; Eur J Clin Nutr, 2020
DOI:
10.1038/s41430-020-00823-z
Identification of a novel uterine leiomyoma GWAS locus in a Japanese population.
Sakai K, Tanikawa C, Hirasawa A, Chiyoda T, Yamagami W, Kataoka F, et al.; Sci Rep 10:1197, 2020
DOI:
10.1038/s41598-020-58066-8
Association of CRX genotypes and retinal phenotypes confounded by variable expressivity and electronegative electroretinogram.
Nishiguchi KM, Kunikata H, Fujita K, Hashimoto K, Koyanagi Y, Akiyama M, et al.; Clin Exp Ophthalmol, 2020
DOI:
10.1111/ceo.13743
The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population.
Nishida Y, Hachiya T, Hara M, Shimanoe C, Tanaka K, Sutoh Y, et al.; J Lipid Res 61:86-94, 2020
DOI:
10.1194/jlr.p091546
Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD).
Ninomiya T, Nakaji S, Maeda T, Yamada M, Mimura M, Nakashima K, et al.; Environ Health Prev Med 25:64, 2020
DOI:
10.1186/s12199-020-00903-3
A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.
Nakamura R, Misawa K, Tohnai G, Nakatochi M, Furuhashi S, Atsuta N, et al.; Commun Biol 3:526, 2020
DOI:
10.1038/s42003-020-01251-2
Variants encoding a restricted carboxy-terminal domain of SLC12A2 cause hereditary hearing loss in humans.
Mutai H, Wasano K, Momozawa Y, Kamatani Y, Miya F, Masuda S, et al.; PLoS Genet 16:e1008643, 2020
DOI:
10.1371/journal.pgen.1008643
日本語解説:
AMED成果情報
Differential effect of polymorphisms on body mass index across the life course of Japanese: the Japan Multi-Institutional Collaborative Cohort Study.
Iwase M, Matsuo K, Nakatochi M, Oze I, Ito H, Koyanagi Y, et al.; J Epidemiol, 2020
DOI:
10.2188/jea.je20190296
High-throughput functional evaluation of BRCA2 variants of unknown significance.
Ikegami M, Kohsaka S, Ueno T, Momozawa Y, Inoue S, Tamura K, et al.; Nat Commun 11:2573, 2020
DOI:
10.1038/s41467-020-16141-8
日本語解説:
AMEDプレスリリース
Diabetes and cancer risk: A Mendelian randomization study.
Goto A, Yamaji T, Sawada N, Momozawa Y, Kamatani Y, Kubo M, et al.; Int J Cancer 146:712-719, 2020
DOI:
10.1002/ijc.32310