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2017

  1. Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.
    Akiyama M, Okada Y, Kanai M, Takahashi A, Momozawa Y, Ikeda M, et al.; Nat Genet 49:1458-1467, 2017
    DOI: 10.1038/ng.3951 　 日本語解説: 理研プレスリリース 　
  2. Genetic Variants of RAMP2 and CLR are Associated with Stroke.
    Koyama T, Kuriyama N, Ozaki E, Matsui D, Watanabe I, Takeshita W, et al.; J Atheroscler Thromb 24:1267-1281, 2017
    DOI: 10.5551/jat.41517 　
  3. Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.
    Xiao X, Wang L, Wang C, Yuan TF, Zhou D, Zheng F, et al.; Transl Psychiatry 7:1273, 2017
    DOI: 10.1038/s41398-017-0019-0 　
  4. Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity.
    Wheeler HE, Gamazon ER, Frisina RD, Perez-Cervantes C, El Charif O, Mapes B, et al.; Clin Cancer Res 23:3325-3333, 2017
    DOI: 10.1158/1078-0432.ccr-16-2809 　
  5. Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.
    van Rooij FJA, Qayyum R, Smith AV, Zhou Y, Trompet S, Tanaka T, et al.; Am J Hum Genet 100:51-63, 2017
    DOI: 10.1016/j.ajhg.2016.11.016 　
  6. Strain-based HLA association analysis identified HLA-DRB1*09:01 associated with modern strain tuberculosis.
    Toyo-Oka L, Mahasirimongkol S, Yanai H, Mushiroda T, Wattanapokayakit S, Wichukchinda N, et al.; HLA 90:149-156, 2017
    DOI: 10.1111/tan.13070 　
  7. Genetic landscape of interactive effects of HLA-DRB1 alleles on susceptibility to ACPA(+) rheumatoid arthritis and ACPA levels in Japanese population.
    Terao C, Okada Y, Ikari K, Kochi Y, Suzuki A, Ohmura K, et al.; J Med Genet 54:853-858, 2017
    DOI: 10.1136/jmedgenet-2017-104779 　
  8. Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
    Telomeres Mendelian Randomization C, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, et al.; JAMA Oncol 3:636-651, 2017
    DOI: 10.1001/jamaoncol.2016.5945 　
  9. Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes: a cross-sectional study in postmenopausal Japanese women.
    Takagi S, Naito M, Kawai S, Okada R, Nagata C, Hosono S, et al.; Br J Nutr 118:463-472, 2017
    DOI: 10.1017/s0007114517002239 　
  10. Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
    Spracklen CN, Chen P, Kim YJ, Wang X, Cai H, Li S, et al.; Hum Mol Genet 26:1770-1784, 2017
    DOI: 10.1093/hmg/ddx062 　
  11. Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations.
    Seow WJ, Matsuo K, Hsiung CA, Shiraishi K, Song M, Kim HN, et al.; Hum Mol Genet 26:454-465, 2017
    DOI: 10.1093/hmg/ddw414 　
  12. Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.
    Sapkota Y, Steinthorsdottir V, Morris AP, Fassbender A, Rahmioglu N, De Vivo I, et al.; Nat Commun 8:15539, 2017
    DOI: 10.1038/ncomms15539 　
  13. Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head.
    Sakamoto Y, Yamamoto T, Sugano N, Takahashi D, Watanabe T, Atsumi T, et al.; Sci Rep 7:15035, 2017
    DOI: 10.1038/s41598-017-14778-y 　
  14. Transethnic Replication Study to Assess the Association Between Clozapine-Induced Agranulocytosis/Granulocytopenia and Genes at 12p12.2 in a Japanese Population.
    Saito T, Ikeda M, Hashimoto R, Iwata N, Members of the Clozapine Pharmacogenomics Consortium of Japan are the f, Yamamori H, et al.; Biol Psychiatry 82:e9-e10, 2017
    DOI: 10.1016/j.biopsych.2016.12.009 　
  15. Genome-wide association study of neovascular age-related macular degeneration in the Thai population.
    Ruamviboonsuk P, Tadarati M, Singhanetr P, Wattanapokayakit S, Kunhapan P, Wanitchanon T, et al.; J Hum Genet 62:957-962, 2017
    DOI: 10.1038/jhg.2017.72 　
  16. Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion.
    Qin S, Ingle JN, Liu M, Yu J, Wickerham DL, Kubo M, et al.; Breast Cancer Res 19:95, 2017
    DOI: 10.1186/s13058-017-0890-x 　
  17. Genome-Wide Association and Replication Study of Hepatotoxicity Induced by Antiretrovirals Alone or with Concomitant Anti-Tuberculosis Drugs.
    Petros Z, Lee MT, Takahashi A, Zhang Y, Yimer G, Habtewold A, et al.; OMICS 21:207-216, 2017
    DOI: 10.1089/omi.2017.0019 　
  18. Pathogen lineage-based genome-wide association study identified CD53 as susceptible locus in tuberculosis.
    Omae Y, Toyo-Oka L, Yanai H, Nedsuwan S, Wattanapokayakit S, Satproedprai N, et al.; J Hum Genet 62:1015-1022, 2017
    DOI: 10.1038/jhg.2017.82 　 日本語解説: AMEDプレスリリース 　
  19. Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer.
    Okada R, Naito M, Hattori Y, Seiki T, Wakai K, Nanri H, et al.; Gastric Cancer 20:246-253, 2017
    DOI: 10.1007/s10120-016-0608-2 　
  20. A functional variant in MIR4300HG, the host gene of microRNA MIR4300 is associated with progression of adolescent idiopathic scoliosis.
    Ogura Y, Kou I, Takahashi Y, Takeda K, Minami S, Kawakami N, et al.; Hum Mol Genet 26:4086-4092, 2017
    DOI: 10.1093/hmg/ddx291 　
  21. Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease.
    Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, et al.; Circ Res 121:81-88, 2017
    DOI: 10.1161/circresaha.117.311145 　
  22. GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes.
    Nakayama A, Nakaoka H, Yamamoto K, Sakiyama M, Shaukat A, Toyoda Y, et al.; Ann Rheum Dis 76:869-877, 2017
    DOI: 10.1136/annrheumdis-2016-209632 　
  23. Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials.
    Magvanjav O, Gong Y, McDonough CW, Chapman AB, Turner ST, Gums JG, et al.; J Am Heart Assoc 6, 2017
    DOI: 10.1161/jaha.117.006522 　
  24. Identification of six new genetic loci associated with atrial fibrillation in the Japanese population.
    Low SK, Takahashi A, Ebana Y, Ozaki K, Christophersen IE, Ellinor PT, et al.; Nat Genet 49:953-958, 2017
    DOI: 10.1038/ng.3842 　 日本語解説: 理研プレスリリース 　
  25. Breast cancer chemoprevention pharmacogenomics: Deep sequencing and functional genomics of the ZNF423 and CTSO genes.
    Liu D, Ho MF, Schaid DJ, Scherer SE, Kalari K, Liu M, et al.; NPJ Breast Cancer 3:30, 2017
    DOI: 10.1038/s41523-017-0036-4 　
  26. A genome-wide association analysis identifies NMNAT2 and HCP5 as susceptibility loci for Kawasaki disease.
    Kim JJ, Yun SW, Yu JJ, Yoon KL, Lee KY, Kil HR, et al.; J Hum Genet 62:1023-1029, 2017
    DOI: 10.1038/jhg.2017.87 　
  27. Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis.
    Ishigaki K, Kochi Y, Suzuki A, Tsuchida Y, Tsuchiya H, Sumitomo S, et al.; Nat Genet 49:1120-1125, 2017
    DOI: 10.1038/ng.3885 　
  28. Fine-mapping inflammatory bowel disease loci to single-variant resolution.
    Huang H, Fang M, Jostins L, Umicevic Mirkov M, Boucher G, Anderson CA, et al.; Nature 547:173-178, 2017
    DOI: 10.1038/nature22969 　
  29. TCL1A Single-Nucleotide Polymorphisms and Estrogen-Mediated Toll-Like Receptor-MYD88-Dependent Nuclear Factor-κB Activation: Single-Nucleotide Polymorphism- and Selective Estrogen Receptor Modulator-Dependent Modification of Inflammation and Immune Response.
    Ho MF, Ingle JN, Bongartz T, Kalari KR, Goss PE, Shepherd LE, et al.; Mol Pharmacol 92:175-184, 2017
    DOI: 10.1124/mol.117.108340 　
  30. ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype.
    Hirabayashi S, Ohki K, Nakabayashi K, Ichikawa H, Momozawa Y, Okamura K, et al.; Haematologica 102:118-129, 2017
    DOI: 10.3324/haematol.2016.151035 　
  31. Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score.
    Hachiya T, Kamatani Y, Takahashi A, Hata J, Furukawa R, Shiwa Y, et al.; Stroke 48:253-258, 2017
    DOI: 10.1161/strokeaha.116.014506 　 日本語解説: AMEDプレスリリース 　
  32. Whole genome sequencing discriminates hepatocellular carcinoma with intrahepatic metastasis from multi-centric tumors.
    Furuta M, Ueno M, Fujimoto A, Hayami S, Yasukawa S, Kojima F, et al.; J Hepatol 66:363-373, 2017
    DOI: 10.1016/j.jhep.2016.09.021 　 日本語解説: 理研プレスリリース
  33. CCDC88B is required for pathogenesis of inflammatory bowel disease.
    Fodil N, Moradin N, Leung V, Olivier JF, Radovanovic I, Jeyakumar T, et al.; Nat Commun 8:932, 2017
    DOI: 10.1038/s41467-017-01381-y 　
  34. Clinical utility and functional analysis of variants in atrial fibrillation-associated locus 4q25.
    Ebana Y, Ozaki K, Liu L, Hachiya H, Hirao K, Isobe M, et al.; J Cardiol 70:366-373, 2017
    DOI: 10.1016/j.jjcc.2016.11.016 　
  35. Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.
    Dujic T, Zhou K, Yee SW, van Leeuwen N, de Keyser CE, Javorsky M, et al.; Clin Pharmacol Ther 101:763-772, 2017
    DOI: 10.1002/cpt.567 　
  36. SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway.
    Dudenkov TM, Ingle JN, Buzdar AU, Robson ME, Kubo M, Ibrahim-Zada I, et al.; Breast Cancer Res Treat 164:189-199, 2017
    DOI: 10.1007/s10549-017-4243-3 　
  37. Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer.
    Dolan ME, El Charif O, Wheeler HE, Gamazon ER, Ardeshir-Rouhani-Fard S, Monahan P, et al.; Clin Cancer Res 23:5757-5768, 2017
    DOI: 10.1158/1078-0432.ccr-16-3224 　
  38. Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
    Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, et al.; Nat Genet 49:946-952, 2017
    DOI: 10.1038/ng.3843 　 日本語解説: AMEDプレスリリース