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過去の業績:2016


  1. Low-frequency coding variants in CETP and CFB are associated with susceptibility of exudative age-related macular degeneration in the Japanese population.
    Momozawa Y, Akiyama M, Kamatani Y, Arakawa S, Yasuda M, Yoshida S, et al.; Hum Mol Genet 25:5027-5034, 2016
    DOI: 10.1093/hmg/ddw335   日本語解説: 理研プレスリリース  
  2. Genetic characteristics of inflammatory bowel disease in a Japanese population.
    Fuyuno Y, Yamazaki K, Takahashi A, Esaki M, Kawaguchi T, Takazoe M, et al.; J Gastroenterol 51:672-81, 2016
    DOI: 10.1007/s00535-015-1135-3  
  3. Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration.
    Yee SW, Momozawa Y, Kamatani Y, Tyndale RF, Weinshilboum RM, Ratain MJ, et al.; Clin Pharmacol Ther 100:423-426, 2016
    DOI: 10.1002/cpt.405  
  4. ABCB1 polymorphism is associated with atorvastatin-induced liver injury in Japanese population.
    Fukunaga K, Nakagawa H, Ishikawa T, Kubo M, Mushiroda T; BMC Genet 17:79, 2016
    DOI: 10.1186/s12863-016-0390-5  
  5. Genome-wide association and replication study of anti-tuberculosis drugs-induced liver toxicity.
    Petros Z, Lee MM, Takahashi A, Zhang Y, Yimer G, Habtewold A, et al.; BMC Genomics 17:755, 2016
    DOI: 10.1186/s12864-016-3078-3  
  6. Associations between Dietary Patterns, ADRβ2 Gln27Glu and ADRβ3 Trp64Arg with Regard to Serum Triglyceride Levels: J-MICC Study.
    Nanri H, Nishida Y, Nakamura K, Tanaka K, Naito M, Yin G, et al.; Nutrients 8, 2016
    DOI: 10.3390/nu8090545  
  7. Effects of self-reported calorie restriction on correlations between SIRT1 polymorphisms and body mass index and long-term weight change.
    Higashibata T, Wakai K, Naito M, Morita E, Hishida A, Hamajima N, et al.; Gene 594:16-22, 2016
    DOI: 10.1016/j.gene.2016.08.051  
  8. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.
    Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, et al.; Nat Genet 48:1055-1059, 2016
    DOI: 10.1038/ng.3632  
  9. Genetic risk score based on the prevalence of vertebral fracture in Japanese women with osteoporosis.
    Zhou H, Mori S, Ishizaki T, Takahashi A, Matsuda K, Koretsune Y, et al.; Bone Rep 5:168-172, 2016
    DOI: 10.1016/j.bonr.2016.07.001  
  10. Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
    Zeng C, Matsuda K, Jia WH, Chang J, Kweon SS, Xiang YB, et al.; Gastroenterology 150:1633-1645, 2016
    DOI: 10.1053/j.gastro.2016.02.076  
  11. ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men.
    Yin G, Naito M, Wakai K, Morita E, Kawai S, Hamajima N, et al.; Nagoya J Med Sci 78:183-93, 2016
    PMCID: PMC4885818  
  12. Variants near the HLA complex group 22 gene (HCG22) confer increased susceptibility to late-onset asthma in Japanese populations.
    Yatagai Y, Hirota T, Sakamoto T, Yamada H, Masuko H, Kaneko Y, et al.; J Allergy Clin Immunol 138:281-283 e13, 2016
    DOI: 10.1016/j.jaci.2015.11.023  
  13. A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN.
    Watanabe H, Atsuta N, Hirakawa A, Nakamura R, Nakatochi M, Ishigaki S, et al.; J Neurol Neurosurg Psychiatry 87:851-8, 2016
    DOI: 10.1136/jnnp-2015-311541  
  14. Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women.
    Wang Z, Seow WJ, Shiraishi K, Hsiung CA, Matsuo K, Liu J, et al.; Hum Mol Genet 25:620-9, 2016
    DOI: 10.1093/hmg/ddv494  
  15. Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.
    van 't Hof FN, Ruigrok YM, Lee CH, Ripke S, Anderson G, de Andrade M, et al.; J Am Heart Assoc 5, 2016
    DOI: 10.1161/JAHA.115.002603  
  16. Variant of the clock circadian regulator (CLOCK) gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population.
    Uemura H, Katsuura-Kamano S, Yamaguchi M, Arisawa K, Hamajima N, Hishida A, et al.; J Diabetes 8:667-76, 2016
    DOI: 10.1111/1753-0407.12344  
  17. PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice.
    Torisu K, Zhang X, Nonaka M, Kaji T, Tsuchimoto D, Kajitani K, et al.; Genes Cells 21:1030-1048, 2016
    DOI: 10.1111/gtc.12402  
  18. High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry.
    Sun C, Molineros JE, Looger LL, Zhou XJ, Kim K, Okada Y, et al.; Nat Genet 48:323-30, 2016
    DOI: 10.1038/ng.3496  
  19. Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols.
    Shiwa Y, Hachiya T, Furukawa R, Ohmomo H, Ono K, Kudo H, et al.; PLoS One 11:e0147519, 2016
    DOI: 10.1371/journal.pone.0147519  
  20. Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.
    Shiraishi K, Okada Y, Takahashi A, Kamatani Y, Momozawa Y, Ashikawa K, et al.; Nat Commun 7:12451, 2016
    DOI: 10.1038/ncomms12451   日本語解説: AMEDプレスリリース  
  21. Genetic Variation in the SLC8A1 Calcium Signaling Pathway Is Associated With Susceptibility to Kawasaki Disease and Coronary Artery Abnormalities.
    Shimizu C, Eleftherohorinou H, Wright VJ, Kim J, Alphonse MP, Perry JC, et al.; Circ Cardiovasc Genet 9:559-568, 2016
    DOI: 10.1161/CIRCGENETICS.116.001533  
  22. NR0B1 Frameshift Mutation in a Boy with Idiopathic Central Precocious Puberty.
    Shima H, Yatsuga S, Nakamura A, Sano S, Sasaki T, Katsumata N, et al.; Sex Dev 10:205-209, 2016
    DOI: 10.1159/000448726  
  23. Pharmacogenomic Study of Clozapine-Induced Agranulocytosis/Granulocytopenia in a Japanese Population.
    Saito T, Ikeda M, Mushiroda T, Ozeki T, Kondo K, Shimasaki A, et al.; Biol Psychiatry 80:636-42, 2016
    DOI: 10.1016/j.biopsych.2015.12.006  
  24. Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis.
    Okada Y, Suzuki A, Ikari K, Terao C, Kochi Y, Ohmura K, et al.; Am J Hum Genet 99:366-74, 2016
    DOI: 10.1016/j.ajhg.2016.06.019  
  25. Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population.
    Nishida Y, Hara M, Sakamoto T, Shinchi K, Kawai S, Naito M, et al.; Prev Med Rep 3:288-95, 2016
    DOI: 10.1016/j.pmedr.2016.03.010  
  26. Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors.
    Middlebrooks CD, Banday AR, Matsuda K, Udquim KI, Onabajo OO, Paquin A, et al.; Nat Genet 48:1330-1338, 2016
    DOI: 10.1038/ng.3670  
  27. Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes.
    Matsuo H, Yamamoto K, Nakaoka H, Nakayama A, Sakiyama M, Chiba T, et al.; Ann Rheum Dis 75:652-9, 2016
    DOI: 10.1136/annrheumdis-2014-206191   日本語解説: 国立遺伝学研究所プレスリリース  
  28. Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity.
    Mahajan A, Rodan AR, Le TH, Gaulton KJ, Haessler J, Stilp AM, et al.; Am J Hum Genet 99:636-646, 2016
    DOI: 10.1016/j.ajhg.2016.07.012  
  29. Association Study of a Functional Variant on ABCG2 Gene with Sunitinib-Induced Severe Adverse Drug Reaction.
    Low SK, Fukunaga K, Takahashi A, Matsuda K, Hongo F, Nakanishi H, et al.; PLoS One 11:e0148177, 2016
    DOI: 10.1371/journal.pone.0148177  
  30. A Genome Wide Study of Copy Number Variation Associated with Nasopharyngeal Carcinoma in Malaysian Chinese Identifies CNVs at 11q14.3 and 6p21.3 as Candidate Loci.
    Low JS, Chin YM, Mushiroda T, Kubo M, Govindasamy GK, Pua KC, et al.; PLoS One 11:e0145774, 2016
    DOI: 10.1371/journal.pone.0145774  
  31. Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans.
    Lee SA, Mefford JA, Huang Y, Witte JS, Martin JN, Haas DW, et al.; AIDS 30:1807-15, 2016
    DOI: 10.1097/QAD.0000000000001124  
  32. A functional SNP in FLT1 increases risk of coronary artery disease in a Japanese population.
    Konta A, Ozaki K, Sakata Y, Takahashi A, Morizono T, Suna S, et al.; J Hum Genet 61:435-41, 2016
    DOI: 10.1038/jhg.2015.171   日本語解説: 理研プレスリリース  
  33. Risk factors and clinical characteristics of the depressive state induced by pegylated interferon therapy in patients with hepatitis C virus infection: A prospective study.
    Kawase K, Kondo K, Saito T, Shimasaki A, Takahashi A, Kamatani Y, et al.; Psychiatry Clin Neurosci 70:489-497, 2016
    DOI: 10.1111/pcn.12424  
  34. Genetic Polymorphisms in the Long Noncoding RNA MIR2052HG Offer a Pharmacogenomic Basis for the Response of Breast Cancer Patients to Aromatase Inhibitor Therapy.
    Ingle JN, Xie F, Ellis MJ, Goss PE, Shepherd LE, Chapman JW, et al.; Cancer Res 76:7012-7023, 2016
    DOI: 10.1158/0008-5472.CAN-16-1371  
  35. Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.
    Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, Grarup N, et al.; Nat Commun 7:10531, 2016
    DOI: 10.1038/ncomms10531  
  36. Genome-wide environment interaction between depressive state and stressful life events.
    Ikeda M, Shimasaki A, Takahashi A, Kondo K, Saito T, Kawase K, et al.; J Clin Psychiatry 77:e29-30, 2016
    DOI: 10.4088/JCP.15l10127  
  37. Estrogen, SNP-Dependent Chemokine Expression and Selective Estrogen Receptor Modulator Regulation.
    Ho MF, Bongartz T, Liu M, Kalari KR, Goss PE, Shepherd LE, et al.; Mol Endocrinol 30:382-98, 2016
    DOI: 10.1210/me.2015-1267  
  38. Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.
    Hertz DL, Owzar K, Lessans S, Wing C, Jiang C, Kelly WK, et al.; Clin Cancer Res 22:4890-4900, 2016
    DOI: 10.1158/1078-0432.CCR-15-2823  
  39. Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.
    Han MR, Long J, Choi JY, Low SK, Kweon SS, Zheng Y, et al.; Hum Mol Genet 25:3361-3371, 2016
    DOI: 10.1093/hmg/ddw164  
  40. TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics.
    Gupta M, Neavin D, Liu D, Biernacka J, Hall-Flavin D, Bobo WV, et al.; Mol Psychiatry 21:1717-1725, 2016
    DOI: 10.1038/mp.2016.6  
  41. A cross-ethnic survey of CFB and SLC44A4, Indian ulcerative colitis GWAS hits, underscores their potential role in disease susceptibility.
    Gupta A, Juyal G, Sood A, Midha V, Yamazaki K, Vich Vila A, et al.; Eur J Hum Genet 25:111-122, 2016
    DOI: 10.1038/ejhg.2016.131  
  42. A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin.
    Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JD, Takahashi A, et al.; Clin Pharmacol Ther 100:537-547, 2016
    DOI: 10.1002/cpt.428  
  43. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
    Fujimoto A, Furuta M, Totoki Y, Tsunoda T, Kato M, Shiraishi Y, et al.; Nat Genet 48:500-9, 2016
    DOI: 10.1038/ng.3547  
  44. Genome-wide association study of leukotriene modifier response in asthma.
    Dahlin A, Litonjua A, Irvin CG, Peters SP, Lima JJ, Kubo M, et al.; Pharmacogenomics J 16:151-7, 2016
    DOI: 10.1038/tpj.2015.34  
  45. Integrated pathway analysis of nasopharyngeal carcinoma implicates the axonemal dynein complex in the Malaysian cohort.
    Chin YM, Tan LP, Abdul Aziz N, Mushiroda T, Kubo M, Mohd Kornain NK, et al.; Int J Cancer 139:1731-9, 2016
    DOI: 10.1002/ijc.30207