Low-frequency coding variants in CETP and CFB are associated with susceptibility of exudative age-related macular degeneration in the Japanese population.
Momozawa Y, Akiyama M, Kamatani Y, Arakawa S, Yasuda M, Yoshida S, et al.; Hum Mol Genet 25:5027-5034, 2016
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10.1093/hmg/ddw335
日本語解説:
理研プレスリリース
Genetic characteristics of inflammatory bowel disease in a Japanese population.
Fuyuno Y, Yamazaki K, Takahashi A, Esaki M, Kawaguchi T, Takazoe M, et al.; J Gastroenterol 51:672-81, 2016
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10.1007/s00535-015-1135-3
Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration.
Yee SW, Momozawa Y, Kamatani Y, Tyndale RF, Weinshilboum RM, Ratain MJ, et al.; Clin Pharmacol Ther 100:423-426, 2016
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10.1002/cpt.405
ABCB1 polymorphism is associated with atorvastatin-induced liver injury in Japanese population.
Fukunaga K, Nakagawa H, Ishikawa T, Kubo M, Mushiroda T; BMC Genet 17:79, 2016
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10.1186/s12863-016-0390-5
Genome-wide association and replication study of anti-tuberculosis drugs-induced liver toxicity.
Petros Z, Lee MM, Takahashi A, Zhang Y, Yimer G, Habtewold A, et al.; BMC Genomics 17:755, 2016
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10.1186/s12864-016-3078-3
Associations between Dietary Patterns, ADRβ2 Gln27Glu and ADRβ3 Trp64Arg with Regard to Serum Triglyceride Levels: J-MICC Study.
Nanri H, Nishida Y, Nakamura K, Tanaka K, Naito M, Yin G, et al.; Nutrients 8, 2016
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10.3390/nu8090545
Effects of self-reported calorie restriction on correlations between SIRT1 polymorphisms and body mass index and long-term weight change.
Higashibata T, Wakai K, Naito M, Morita E, Hishida A, Hamajima N, et al.; Gene 594:16-22, 2016
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10.1016/j.gene.2016.08.051
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.
Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, et al.; Nat Genet 48:1055-1059, 2016
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10.1038/ng.3632
Genetic risk score based on the prevalence of vertebral fracture in Japanese women with osteoporosis.
Zhou H, Mori S, Ishizaki T, Takahashi A, Matsuda K, Koretsune Y, et al.; Bone Rep 5:168-172, 2016
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10.1016/j.bonr.2016.07.001
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
Zeng C, Matsuda K, Jia WH, Chang J, Kweon SS, Xiang YB, et al.; Gastroenterology 150:1633-1645, 2016
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10.1053/j.gastro.2016.02.076
ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men.
Yin G, Naito M, Wakai K, Morita E, Kawai S, Hamajima N, et al.; Nagoya J Med Sci 78:183-93, 2016
PMCID:
PMC4885818
Variants near the HLA complex group 22 gene (HCG22) confer increased susceptibility to late-onset asthma in Japanese populations.
Yatagai Y, Hirota T, Sakamoto T, Yamada H, Masuko H, Kaneko Y, et al.; J Allergy Clin Immunol 138:281-283 e13, 2016
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10.1016/j.jaci.2015.11.023
A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN.
Watanabe H, Atsuta N, Hirakawa A, Nakamura R, Nakatochi M, Ishigaki S, et al.; J Neurol Neurosurg Psychiatry 87:851-8, 2016
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10.1136/jnnp-2015-311541
Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women.
Wang Z, Seow WJ, Shiraishi K, Hsiung CA, Matsuo K, Liu J, et al.; Hum Mol Genet 25:620-9, 2016
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Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.
van 't Hof FN, Ruigrok YM, Lee CH, Ripke S, Anderson G, de Andrade M, et al.; J Am Heart Assoc 5, 2016
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10.1161/JAHA.115.002603
Variant of the clock circadian regulator (CLOCK) gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population.
Uemura H, Katsuura-Kamano S, Yamaguchi M, Arisawa K, Hamajima N, Hishida A, et al.; J Diabetes 8:667-76, 2016
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PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice.
Torisu K, Zhang X, Nonaka M, Kaji T, Tsuchimoto D, Kajitani K, et al.; Genes Cells 21:1030-1048, 2016
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10.1111/gtc.12402
High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry.
Sun C, Molineros JE, Looger LL, Zhou XJ, Kim K, Okada Y, et al.; Nat Genet 48:323-30, 2016
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Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols.
Shiwa Y, Hachiya T, Furukawa R, Ohmomo H, Ono K, Kudo H, et al.; PLoS One 11:e0147519, 2016
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Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.
Shiraishi K, Okada Y, Takahashi A, Kamatani Y, Momozawa Y, Ashikawa K, et al.; Nat Commun 7:12451, 2016
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日本語解説:
AMEDプレスリリース
Genetic Variation in the SLC8A1 Calcium Signaling Pathway Is Associated With Susceptibility to Kawasaki Disease and Coronary Artery Abnormalities.
Shimizu C, Eleftherohorinou H, Wright VJ, Kim J, Alphonse MP, Perry JC, et al.; Circ Cardiovasc Genet 9:559-568, 2016
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10.1161/CIRCGENETICS.116.001533
NR0B1 Frameshift Mutation in a Boy with Idiopathic Central Precocious Puberty.
Shima H, Yatsuga S, Nakamura A, Sano S, Sasaki T, Katsumata N, et al.; Sex Dev 10:205-209, 2016
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10.1159/000448726
Pharmacogenomic Study of Clozapine-Induced Agranulocytosis/Granulocytopenia in a Japanese Population.
Saito T, Ikeda M, Mushiroda T, Ozeki T, Kondo K, Shimasaki A, et al.; Biol Psychiatry 80:636-42, 2016
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10.1016/j.biopsych.2015.12.006
Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis.
Okada Y, Suzuki A, Ikari K, Terao C, Kochi Y, Ohmura K, et al.; Am J Hum Genet 99:366-74, 2016
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10.1016/j.ajhg.2016.06.019
Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population.
Nishida Y, Hara M, Sakamoto T, Shinchi K, Kawai S, Naito M, et al.; Prev Med Rep 3:288-95, 2016
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10.1016/j.pmedr.2016.03.010
Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors.
Middlebrooks CD, Banday AR, Matsuda K, Udquim KI, Onabajo OO, Paquin A, et al.; Nat Genet 48:1330-1338, 2016
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10.1038/ng.3670
Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes.
Matsuo H, Yamamoto K, Nakaoka H, Nakayama A, Sakiyama M, Chiba T, et al.; Ann Rheum Dis 75:652-9, 2016
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10.1136/annrheumdis-2014-206191
日本語解説:
国立遺伝学研究所プレスリリース
Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity.
Mahajan A, Rodan AR, Le TH, Gaulton KJ, Haessler J, Stilp AM, et al.; Am J Hum Genet 99:636-646, 2016
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10.1016/j.ajhg.2016.07.012
Association Study of a Functional Variant on ABCG2 Gene with Sunitinib-Induced Severe Adverse Drug Reaction.
Low SK, Fukunaga K, Takahashi A, Matsuda K, Hongo F, Nakanishi H, et al.; PLoS One 11:e0148177, 2016
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10.1371/journal.pone.0148177
A Genome Wide Study of Copy Number Variation Associated with Nasopharyngeal Carcinoma in Malaysian Chinese Identifies CNVs at 11q14.3 and 6p21.3 as Candidate Loci.
Low JS, Chin YM, Mushiroda T, Kubo M, Govindasamy GK, Pua KC, et al.; PLoS One 11:e0145774, 2016
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10.1371/journal.pone.0145774
Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans.
Lee SA, Mefford JA, Huang Y, Witte JS, Martin JN, Haas DW, et al.; AIDS 30:1807-15, 2016
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10.1097/QAD.0000000000001124
A functional SNP in FLT1 increases risk of coronary artery disease in a Japanese population.
Konta A, Ozaki K, Sakata Y, Takahashi A, Morizono T, Suna S, et al.; J Hum Genet 61:435-41, 2016
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10.1038/jhg.2015.171
日本語解説:
理研プレスリリース
Risk factors and clinical characteristics of the depressive state induced by pegylated interferon therapy in patients with hepatitis C virus infection: A prospective study.
Kawase K, Kondo K, Saito T, Shimasaki A, Takahashi A, Kamatani Y, et al.; Psychiatry Clin Neurosci 70:489-497, 2016
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10.1111/pcn.12424
Genetic Polymorphisms in the Long Noncoding RNA MIR2052HG Offer a Pharmacogenomic Basis for the Response of Breast Cancer Patients to Aromatase Inhibitor Therapy.
Ingle JN, Xie F, Ellis MJ, Goss PE, Shepherd LE, Chapman JW, et al.; Cancer Res 76:7012-7023, 2016
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10.1158/0008-5472.CAN-16-1371
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.
Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, Grarup N, et al.; Nat Commun 7:10531, 2016
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10.1038/ncomms10531
Genome-wide environment interaction between depressive state and stressful life events.
Ikeda M, Shimasaki A, Takahashi A, Kondo K, Saito T, Kawase K, et al.; J Clin Psychiatry 77:e29-30, 2016
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10.4088/JCP.15l10127
Estrogen, SNP-Dependent Chemokine Expression and Selective Estrogen Receptor Modulator Regulation.
Ho MF, Bongartz T, Liu M, Kalari KR, Goss PE, Shepherd LE, et al.; Mol Endocrinol 30:382-98, 2016
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10.1210/me.2015-1267
Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.
Hertz DL, Owzar K, Lessans S, Wing C, Jiang C, Kelly WK, et al.; Clin Cancer Res 22:4890-4900, 2016
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10.1158/1078-0432.CCR-15-2823
Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.
Han MR, Long J, Choi JY, Low SK, Kweon SS, Zheng Y, et al.; Hum Mol Genet 25:3361-3371, 2016
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10.1093/hmg/ddw164
TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics.
Gupta M, Neavin D, Liu D, Biernacka J, Hall-Flavin D, Bobo WV, et al.; Mol Psychiatry 21:1717-1725, 2016
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10.1038/mp.2016.6
A cross-ethnic survey of CFB and SLC44A4, Indian ulcerative colitis GWAS hits, underscores their potential role in disease susceptibility.
Gupta A, Juyal G, Sood A, Midha V, Yamazaki K, Vich Vila A, et al.; Eur J Hum Genet 25:111-122, 2016
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10.1038/ejhg.2016.131
A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin.
Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JD, Takahashi A, et al.; Clin Pharmacol Ther 100:537-547, 2016
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10.1002/cpt.428
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
Fujimoto A, Furuta M, Totoki Y, Tsunoda T, Kato M, Shiraishi Y, et al.; Nat Genet 48:500-9, 2016
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10.1038/ng.3547
Genome-wide association study of leukotriene modifier response in asthma.
Dahlin A, Litonjua A, Irvin CG, Peters SP, Lima JJ, Kubo M, et al.; Pharmacogenomics J 16:151-7, 2016
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10.1038/tpj.2015.34
Integrated pathway analysis of nasopharyngeal carcinoma implicates the axonemal dynein complex in the Malaysian cohort.
Chin YM, Tan LP, Abdul Aziz N, Mushiroda T, Kubo M, Mohd Kornain NK, et al.; Int J Cancer 139:1731-9, 2016
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10.1002/ijc.30207