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過去の業績:2015


  1. A genome-wide association study of periodontitis in a Japanese population.
    Shimizu S*, Momozawa Y*, Takahashi A, Nagasawa T, Ashikawa K, Terada Y, et al.; J Dent Res 94:555-61, 2015
    DOI: 10.1177/0022034515570315  
  2. A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese.
    Hirokawa M, Morita H, Tajima T, Takahashi A, Ashikawa K, Miya F, et al.; Eur J Hum Genet 23:374-80, 2015
    DOI: 10.1038/ejhg.2014.110  
  3. A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.
    Hirano A, Ohara T, Takahashi A, Aoki M, Fuyuno Y, Ashikawa K, et al.; Psychiatr Genet 25:139-46, 2015
    DOI: 10.1097/YPG.0000000000000090  
  4. Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese.
    Okada Y, Momozawa Y, Ashikawa K, Kanai M, Matsuda K, Kamatani Y, et al.; Nat Genet 47:798-802, 2015
    DOI: 10.1038/ng.3310  
  5. Performance comparison of four commercial human whole-exome capture platforms.
    Shigemizu D, Momozawa Y, Abe T, Morizono T, Boroevich KA, Takata S, et al.; Sci Rep 5:12742, 2015
    DOI: 10.1038/srep12742   日本語解説: 理研プレスリリース  
  6. Genome-Wide Association Study of Peripheral Arterial Disease in a Japanese Population.
    Matsukura M, Ozaki K, Takahashi A, Onouchi Y, Morizono T, Komai H, et al.; PLoS One 10:e0139262, 2015
    DOI: 10.1371/journal.pone.0139262   日本語解説: 理研プレスリリース  
  7. A deletion mutation in myosin heavy chain 11 causing familial thoracic aortic dissection in two Japanese pedigrees.
    Imai Y, Morita H, Takeda N, Miya F, Hyodo H, Fujita D, et al.; Int J Cardiol 195:290-2, 2015
    DOI: 10.1016/j.ijcard.2015.05.178  
  8. Association of Genetically Determined Aldehyde Dehydrogenase 2 Activity with Diabetic Complications in Relation to Alcohol Consumption in Japanese Patients with Type 2 Diabetes Mellitus: The Fukuoka Diabetes Registry.
    Idewaki Y, Iwase M, Fujii H, Ohkuma T, Ide H, Kaizu S, et al.; PLoS One 10:e0143288, 2015
    DOI: 10.1371/journal.pone.0143288  
  9. Endothelin-1 Pathway Polymorphisms and Outcomes in Pulmonary Arterial Hypertension.
    Benza RL, Gomberg-Maitland M, Demarco T, Frost AE, Torbicki A, Langleben D, et al.; Am J Respir Crit Care Med 192:1345-54, 2015
    DOI: 10.1164/rccm.201501-0196OC  
  10. Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study.
    Yamaguchi M, Uemura H, Arisawa K, Katsuura-Kamano S, Hamajima N, Hishida A, et al.; Diabetes Res Clin Pract 110:301-8, 2015
    DOI: 10.1016/j.diabres.2015.10.009  
  11. Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.
    Wang M, Takahashi A, Liu F, Ye D, Ding Q, Qin C, et al.; Nat Commun 6:8469, 2015
    DOI: 10.1038/ncomms9469  
  12. A polygenic risk score for breast cancer in women receiving tamoxifen or raloxifene on NSABP P-1 and P-2.
    Vachon CM, Schaid DJ, Ingle JN, Wickerham DL, Kubo M, Mushiroda T, et al.; Breast Cancer Res Treat 149:517-23, 2015
    DOI: 10.1007/s10549-014-3175-4  
  13. IKZF1, a new susceptibility gene for cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement.
    Ueta M, Sawai H, Sotozono C, Hitomi Y, Kaniwa N, Kim MK, et al.; J Allergy Clin Immunol 135:1538-45 e17, 2015
    DOI: 10.1016/j.jaci.2014.12.1916  
  14. An association between amino acid position 74 of HLA-DRB1 and anti-citrullinated protein antibody levels in Japanese patients with anti-citrullinated protein antibody-positive rheumatoid arthritis.
    Terao C, Suzuki A, Ikari K, Kochi Y, Ohmura K, Katayama M, et al.; Arthritis Rheumatol 67:2038-45, 2015
    DOI: 10.1002/art.39133  
  15. Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population.
    Terao C, Ohmura K, Kochi Y, Ikari K, Okada Y, Shimizu M, et al.; Arthritis Res Ther 17:104, 2015
    DOI: 10.1186/s13075-015-0623-4  
  16. Associations between polymorphisms of interleukin-6 and related cytokine genes and serum liver damage markers: a cross-sectional study in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.
    Sugimoto Y, Wakai K, Nakagawa H, Suma S, Sasakabe T, Sakamoto T, et al.; Gene 557:158-62, 2015
    DOI: 10.1016/j.gene.2014.12.025  
  17. Exome Analyses of Long QT Syndrome Reveal Candidate Pathogenic Mutations in Calmodulin-Interacting Genes.
    Shigemizu D, Aiba T, Nakagawa H, Ozaki K, Miya F, Satake W, et al.; PLoS One 10:e0130329, 2015
    DOI: 10.1371/journal.pone.0130329  
  18. Association between endometriosis and the interleukin 1A (IL1A) locus.
    Sapkota Y, Low SK, Attia J, Gordon SD, Henders AK, Holliday EG, et al.; Hum Reprod 30:239-48, 2015
    DOI: 10.1093/humrep/deu267  
  19. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
    Paternoster L, Standl M, Waage J, Baurecht H, Hotze M, Strachan DP, et al.; Nat Genet 47:1449-1456, 2015
    DOI: 10.1038/ng.3424  
  20. Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy.
    Ono A, Fujimoto A, Yamamoto Y, Akamatsu S, Hiraga N, Imamura M, et al.; Cell Mol Gastroenterol Hepatol 1:516-534, 2015
    DOI: 10.1016/j.jcmgh.2015.06.009  
  21. A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis.
    Ogura Y, Kou I, Miura S, Takahashi A, Xu L, Takeda K, et al.; Am J Hum Genet 97:337-42, 2015
    DOI: 10.1016/j.ajhg.2015.06.012  
  22. Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population.
    Matsuda K, Takahashi A, Middlebrooks CD, Obara W, Nasu Y, Inoue K, et al.; Hum Mol Genet 24:1177-84, 2015
    DOI: 10.1093/hmg/ddu512  
  23. Genetic studies of body mass index yield new insights for obesity biology.
    Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, et al.; Nature 518:197-206, 2015
    DOI: 10.1038/nature14177  
  24. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
    Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, et al.; Nat Genet 47:979-986, 2015
    DOI: 10.1038/ng.3359  
  25. Genetic variants of SLC17A1 are associated with cholesterol homeostasis and hyperhomocysteinaemia in Japanese men.
    Koyama T, Matsui D, Kuriyama N, Ozaki E, Tanaka K, Oze I, et al.; Sci Rep 5:15888, 2015
    DOI: 10.1038/srep15888  
  26. Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy.
    Komatsu M, Wheeler HE, Chung S, Low SK, Wing C, Delaney SM, et al.; Clin Cancer Res 21:4337-46, 2015
    DOI: 10.1158/1078-0432.CCR-15-0133  
  27. Influence of Genetic Variants in EGF and Other Genes on Hematological Traits in Korean Populations by a Genome-Wide Approach.
    Kim YK, Oh JH, Kim YJ, Hwang MY, Moon S, Low SK, et al.; Biomed Res Int 2015:914965, 2015
    DOI: 10.1155/2015/914965  
  28. Genome-wide association study of recalcitrant atopic dermatitis in Korean children.
    Kim KW, Myers RA, Lee JH, Igartua C, Lee KE, Kim YH, et al.; J Allergy Clin Immunol 136:678-684 e4, 2015
    DOI: 10.1016/j.jaci.2015.03.030  
  29. Directional dominance on stature and cognition in diverse human populations.
    Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, et al.; Nature 523:459-462, 2015
    DOI: 10.1038/nature14618   日本語解説: 理研プレスリリース  
  30. Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women.
    Hosono S, Ito H, Oze I, Higaki Y, Morita E, Takashima N, et al.; Maturitas 82:394-401, 2015
    DOI: 10.1016/j.maturitas.2015.08.003  
  31. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, et al.; Hum Mol Genet 24:1791-800, 2015
    DOI: 10.1093/hmg/ddu583  
  32. Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions.
    Han Y, Hazelett DJ, Wiklund F, Schumacher FR, Stram DO, Berndt SI, et al.; Hum Mol Genet 24:5603-18, 2015
    DOI: 10.1093/hmg/ddv269  
  33. PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.
    Gong Y, McDonough CW, Beitelshees AL, El Rouby N, Hiltunen TP, O'Connell JR, et al.; J Hypertens 33:2278-85, 2015
    DOI: 10.1097/HJH.0000000000000714  
  34. Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity.
    Fujimoto A, Furuta M, Shiraishi Y, Gotoh K, Kawakami Y, Arihiro K, et al.; Nat Commun 6:6120, 2015
    DOI: 10.1038/ncomms7120   日本語解説: 理研プレスリリース  
  35. Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma.
    Dahlin A, Litonjua A, Lima JJ, Tamari M, Kubo M, Irvin CG, et al.; PLoS One 10:e0129385, 2015
    DOI: 10.1371/journal.pone.0129385  
  36. CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids.
    Dahlin A, Denny J, Roden DM, Brilliant MH, Ingram C, Kitchner TE, et al.; Immun Inflamm Dis 3:350-9, 2015
    DOI: 10.1002/iid3.73  
  37. HLA-A SNPs and amino acid variants are associated with nasopharyngeal carcinoma in Malaysian Chinese.
    Chin YM, Mushiroda T, Takahashi A, Kubo M, Krishnan G, Yap LF, et al.; Int J Cancer 136:678-87, 2015
    DOI: 10.1002/ijc.29035  
  38. The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response.
    Biernacka JM, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, et al.; Transl Psychiatry 5:e553, 2015
    DOI: 10.1038/tp.2015.47  
  39. Disease susceptibility genes shared by primary biliary cirrhosis and Crohn's disease in the Japanese population.
    Aiba Y, Yamazaki K, Nishida N, Kawashima M, Hitomi Y, Nakamura H, et al.; J Hum Genet 60:525-31, 2015
    DOI: 10.1038/jhg.2015.59