Laboratory for Retrotransposon Dynamics

Laboratory for Retrotransposon Dynamics

RIKEN Center for Integrative Medical Sciences (IMS) @ Yokohama
Team Leader: Tomoichiro Miyoshi

Research Topics

Our group is interested in investigating transposable elements (TEs) or "jumping genes" that comprise ~45% of the human genome. These elements can mobilize within the genome, which may provide intra- or inter-genetic variation, and a driving force in genome evolution; however, TE insertions can also cause gene disruption associated with sporadic genetic diseases. Specifically, we are interested in uncovering the mechanisms that regulate LINE-1 and SINE retrotransposons and their impacts on the genome and diseases. Our group focuses on (1) the dynamic regulation of how mammalian retrotransposons mobilize in our genome, and (2) the mechanisms of aging and immune responses that retrotransposons facilitate. In the future, we aim to establish techniques to control the retrotransposon activities, thereby developing methods to suppress disease-associated phenotypes induced by retrotransposons. See more details >>


Contact Information


East Research Bld. 4F,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama, Kanagawa,
230-0045, Japan



If you want to know more details, please email us.
tomoichiro.miyoshi [at]


Our group always welcomes the participation of motivated graduate students and post-doctoral fellows!! RIKEN offers JRA, RSR, and other support services to graduate students, so please contact us if you are interested.


We are also currently looking for postdoctoral fellows. RIKEN has many overseas researchers and provides excellent opportunities to promote international collaboration, so please apply whether you are in Japan or overseas! We now have two positions available for postdoc. Please check this site. You can also apply for RIKEN SPDR or JSPS PD as a postdoc position in our lab, which will be supported with RIKEN or JSPS reseach budget, respectively.