Research History

Selected paper

1. Helicobacter pylori, homologous recombination genes and gastric cancer
   Usui Y, Taniyama Y, Endo M, Koyanagi Y, Kasugai Y, Oze I, Ito H, Imoto I, Tanaka T, Tajika M, Niwa Y, Iwasaki Y, Aoi T, Hakozaki N, Takata S, Suzuki K, Terao C, Hatakeyama M, Hirata M, Sugano K, Yoshida T, Kamatani Y, Nakagawa H, Matsuda K, Murakami Y, Spurdle A, Matsuo K*, Momozawa Y*; N Engl J Med 388:1181-1190, 2023
   DOI: 10.1056/NEJMoa2211807 　 Summary: RIKEN Press Release
2. Hereditary cancer variants and homologous recombination deficiency in biliary tract cancer.
   Okawa Y, Iwasaki Y, Johnson TA, Ebata N, Inai C, Endo M, Maejima K, Sasagawa S, Fujita M, Matsuda K, Murakami Y, Nakamura T, Hirano S, Momozawa Y*, Nakagawa H*; J Hepatol 78:333-342, 2023
   DOI: 10.1016/j.jhep.2022.09.025 　
3. Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants.
   Momozawa Y, Sasai R, Usui Y, Shiraishi K, Iwasaki Y, Taniyama Y, Parsons MT, Mizukami K, Sekine Y, Hirata M, Kamatani Y, Endo M, Inai C, Takata S, Ito H, Kohno T, Matsuda K, Nakamura S, Sugano K, Yoshida T, Nakagawa H, Matsuo K, Murakami Y, Spurdle AB, Kubo M; JAMA Oncol 8:871-878, 2022
   DOI: 10.1001/jamaoncol.2022.0476 　
4. Population-based Screening for Hereditary Colorectal Cancer Variants in Japan.
   Fujita M, Liu XX, Iwasaki Y, Terao C, Mizukami K, Kawakami E, Takata S, Inai C, Aoi T, Mizukoshi M, Maejima K, Hirata M, Murakami Y, Kamatani Y, Kubo M, Akagi K, Matsuda K, Nakagawa H*, Momozawa Y*; Clin Gastroenterol Hepatol 20:2132-2141.e9, 2022
   DOI: 10.1016/j.cgh.2020.12.007 　
5. Genome wide association study of 40 clinical measurements in eight dog breeds.
   Momozawa Y*, Merveille AC, Battaille G, Wiberg M, Koch J, Willesen JL, Proschowsky HF, Gouni V, Chetboul V, Tiret L, Fredholm M, Seppala EH, Lohi H, Georges M, Lequarre AS*; Sci Rep 10:6520, 2020
   DOI: 10.1038/s41598-020-63457-y 　
6. Germline Pathogenic Variants in 7,636 Japanese Patients With Prostate Cancer and 12 366 Controls.
   Momozawa Y, Iwasaki Y, Hirata M, Liu XX, Kamatani Y, Takahashi A, Sugano K, Yoshida T, Murakami Y, Matsuda K, Nakagawa H, Spurdle AB, Kubo M; J Natl Cancer Inst 112:369-376, 2019
   DOI: 10.1093/jnci/djz124 　
7. Genetic characterization of pancreatic cancer patients and prediction of carrier status of germline pathogenic variants in cancer-predisposing genes.
   Mizukami K, Iwasaki Y, Kawakami E, Hirata M, Kamatani Y, Matsuda K, Endo M, Sugano K, Yoshida T, Murakami Y, Nakagawa H, Spurdle AB, Momozawa Y; EBioMedicine 60:103033, 2020
   DOI: 10.1016/j.ebiom.2020.103033 　
8. Identification of rare coding variants in TYK2 protective for rheumatoid arthritis in the Japanese population and their effects on cytokine signalling.
   Motegi T, Kochi Y, Matsuda K, Kubo M, Yamamoto K, Momozawa Y; Ann Rheum Dis 78:1062-1069, 2019
   DOI: 10.1136/annrheumdis-2019-215062 　
9. Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls.
   Momozawa Y*, Iwasaki Y, Parsons MT, Kamatani Y, Takahashi A, Tamura C, Katagiri T, Yoshida T, Nakamura S, Sugano K, Miki Y, Hirata M, Matsuda K, Spurdle AB, Kubo M*; Nat Commun 9:4083, 2018
   DOI: 10.1038/s41467-018-06581-8 　
10. IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes.
    Momozawa Y, Dmitrieva J, Theatre E, Deffontaine V, Rahmouni S, Charloteaux B, Crins F, Docampo E, Elansary M, Gori AS, Lecut C, Mariman R, Mni M, Oury C, Altukhov I, Alexeev D, Aulchenko Y, Amininejad L, Bouma G, Hoentjen F, Lowenberg M, Oldenburg B, Pierik MJ, vander Meulen-de Jong AE, van der Woude CJ, Visschedijk MC, Lathrop M, Hugot JP, Weersma RK, De Vos M, Franchimont D, Vermeire S, Kubo M, Louis E, Georges M, Abraham C, Achkar JP, Ahmad T, Ananthakrishnan AN, Andersen V, Anderson CA, Andrews JM, Annese V, Aumais G, Baidoo L, Baldassano RN, Bampton PA, Barclay M, Barrett JC, Bayless TM, Bethge J, Bitton A, Boucher G, Brand S, Brandt B, Brant SR, Buning C, Chew A, Cho JH, Cleynen I, Cohain A, Croft A, Daly MJ, D'Amato M, Danese S, De Jong D, Denapiene G, Denson LA, Devaney KL, Dewit O, D'Inca R, Dubinsky M, Duerr RH, Edwards C, Ellinghaus D, Essers J, Ferguson LR, Festen EA, Fleshner P, Florin T, Franke A, Fransen K, Gearry R, Gieger C, Glas J, Goyette P, Green T, Griffiths AM, Guthery SL, Hakonarson H, Halfvarson J, Hanigan K, Haritunians T, Hart A, Hawkey C, Hayward NK, Hedl M, Henderson P, Hu XH, Huang HL, Hui KY, Imielinski M, Ippoliti A, Jonaitis L, Jostins L, Karlsen TH, Kennedy NA, Khan MA, Kiudelis G, Krishnaprasad K, Kugathasan S, Kupcinskas L, Latiano A, Laukens D, Lawrance IC, Lee JC, Lees CW, Leja M, Van Limbergen J, Lionetti P, Liu JZ, Mahy G, Mansfield J, Massey D, Mathew CG, McGovern DPB, Milgrom R, Mitrovic M, Montgomery GW, Mowat C, Newman W, Ng A, Ng SC, Ng SME, Nikolaus S, Ning K, Nothen M, Oikonomou I, Palmieri O, Parkes M, Phillips A, Ponsioen CY, Potocnik U, Prescott NJ, Proctor DD, Radford-Smith G, Rahier JF, Raychaudhuri S, Regueiro M, Rieder F, Rioux JD, Ripke S, Roberts R, Russell RK, Sanderson JD, Sans M, Satsangi J, Schadt EE, Schreiber S, Schulte D, Schumm LP, Scott R, Seielstad M, Sharma Y, Silverberg MS, Simms LA, Skieceviciene J, Spain SL, Steinhart AH, Stempak JM, Stronati L, Sventoraityte J, Targan SR, Taylor KM, ter Velde A, Torkvist L, Tremelling M, van Sommeren S, Vasiliauskas E, Verspaget HW, Walters T, Wang K, Wang MH, Wei Z, Whiteman D, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Zhang B, Zhang CK, Zhang H, Zhang W, Zhao HY, Zhao ZZ, Int IBDGC; Nat Commun 9:2427, 2018
    DOI: 10.1038/s41467-018-04365-8 　
11. Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease.
    Momozawa Y, Mni M, Nakamura K, Coppieters W, Almer S, Amininejad L, Cleynen I, Colombel JF, de Rijk P, Dewit O, Finkel Y, Gassull MA, Goossens D, Laukens D, Lemann M, Libioulle C, O'Morain C, Reenaers C, Rutgeerts P, Tysk C, Zelenika D, Lathrop M, Del-Favero J, Hugot JP, de Vos M, Franchimont D, Vermeire S, Louis E, Georges M; Nat Genet 43:43-47, 2011
    DOI: 10.1038/ng.733 　
12. Association between equine temperament and polymorphisms in dopamine D4 receptor gene.
    Momozawa Y, Takeuchi Y, Kusunose R, Kikusui T, Mori Y; Mamm Genome 16:538-544, 2005
    DOI: 10.1007/s00335-005-0021-3 　
13. Assessment of equine temperament by a questionnaire survey to caretakers and evaluation of its reliability by simultaneous behavior test.
    Momozawa Y, Ono T, Sato F, Kikusui T, Takeuchi Y, Mori Y, Kusunose R; Appl Anim Behav Sci 84:127-138, 2003
    DOI: 10.1016/j.applanim.2003.08.001 　

• *: co-corresponding author